Disruption of lateral hypothalamic calorie detection by a free choice high fat diet

During the last few decades, consumption of low-calorie sweeteners, as a substitute for caloric has sharply increased. Although research shows that versus sweeteners can have differential effects on brain, it is unknown which neuronal populations are responsible detecting difference between two types sweeteners. Using in vivo two-photon calcium imaging, we investigated how drinking sucrose or sucralose (a sweetener) affects activity glutamatergic neurons lateral hypothalamus. Furthermore, explored consequences consuming free-choice high fat diet calorie detection abilities these neurons. We found indeed discriminate from water and sucralose, shifts response sucrose-specific to sucralose-specific, thereby disrupting detection. These results highlight disruptive saturated